F-CHEM

Application

1. Sticky phlegm is difficult to cough up

The sulfhydryl group in the structure of acetylcysteine can break the disulfide bond of mucin, reduce the viscosity of sputum, and make sputum easy to cough up. Because this drug can liquefy the secretions in the bronchi and increase the amount of secretions (mainly in the early stage of medication), attention must be paid to whether the patient can effectively expel sputum. If necessary, the secretions should be discharged by postural drainage or bronchial suction to avoid secretions. Retention blocks the airway.

2. Paracetamol poisoning

According to the “Guidelines for the Diagnosis and Treatment of Drug-Induced Liver Injury” 2015 edition, acetaminophen is the main cause of acute liver failure (ALF), and N-acetylcysteine inhibits the binding of toxic metabolites to liver cell proteins and acts as a Mechanisms such as the precursor of glutathione reduce liver damage.

3. Eye diseases (punctate keratitis, herpes simplex keratitis, etc.)

Acetylcysteine is a collagenase inhibitor. On the one hand, it can complex calcium ions to indirectly inhibit collagenase; Loss of activity directly and irreversibly inhibits collagenase, reducing the breakdown of collagen in tissues. In addition, acetylcysteine can improve cell respiration and tissue nutrition, promote corneal epithelial regeneration, and improve eye metabolism.

4. Liver failure

Acetylcysteine is the precursor of reduced glutathione (GSH), which is an oxygen free radical scavenger in the body. The mechanism of its hepatoprotective effect is not very clear, and it may be related to maintaining or restoring glutathione levels. In addition, acetylcysteine may also play a hepatoprotective role by improving hemodynamics and oxygen transport capacity and expanding microcirculation.

5. Idiopathic pulmonary fibrosis

Acetylcysteine can pass through cell membranes and be converted to cysteine, a precursor of glutathione. The study found that administration of acetylcysteine increased glutathione levels in alveolar lavage fluid while reducing levels of the oxidative stress marker methionine sulfoxide. Acetylcysteine can also reduce lung damage by scavenging oxygen free radicals.

According to reports by Fu Xiaowei et al., long-term use of acetylcysteine may improve the clinical condition and lung function of patients with idiopathic pulmonary fibrosis, and has less adverse reactions, high safety, and relatively cheap price.

6. Contrast nephropathy

Acetylcysteine is a sulfhydryl-containing antioxidant and the precursor of reduced glutathione. It can not only interfere with the generation of oxygen free radicals, regulate cell metabolism, but also inhibit the activity of angiotensin-converting enzymes to reduce vascular tension. It can induce the expression of NO enzyme in the vascular endothelium to promote the release of NO, and increase the biological activity of NO; in addition, it can also expand the renal blood vessels to improve renal blood flow.

According to related reports, the combined application of hydration and acetylcysteine can prevent the occurrence of contrast-induced nephropathy, and the difference is statistically significant compared with hydration treatment alone, indicating that the application of acetylcysteine on the basis of hydration treatment, It is more beneficial to reduce the occurrence of contrast-induced nephropathy. The application of acetylcysteine on the basis of hydration has a significant effect in preventing contrast-induced nephropathy.

Packing:

25kg/drum

Specification

latest EP、USP