CAS No.:89-57-6
Mesalazine
Synonyms: 5-Amino Salicylic Acid
Molecular Formula: C7H7NO3
CAS No: 89-57-6
UN No.: N/A
Properties: Mesalazine is an anti-ulcer drug. By acting on the intestinal inflammatory mucosa, it inhibits the synthesis of prostaglandins that cause inflammation and the formation of inflammatory mediators leukotrienes, thereby having a significant anti-inflammatory effect on intestinal wall inflammation. The effect is especially good on the connective tissue of the wall.
Application
The colonic mucosa of patients with active UC has high levels of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4). Mesalazine can inhibit the synthesis of prostaglandins in a dose-dependent manner and reduce the release of PGE2 in the human colonic mucosa. In addition, mesalazine can also inhibit the lipoxygenase activity of neutrophils. Adding mesalazine to culture human colonic mucosal cells can inhibit two important inflammatory mediators—chemotactic LTB4 and leukotrienes in a dose-effect manner. At high doses, mesalazine can inhibit certain functions of human neutrophils, such as migration, degranulation, phagocytosis and synthesis of oxygen free radicals. In addition, mesalazine can also inhibit the synthesis of platelet activity factor (PAF), which plays an important role in inflammation. It works best on the connective tissue of the inflamed bowel wall. For ulcerative colitis, ulcerative proctitis, and Crohn’s disease.
It has a significant inhibitory effect on intestinal wall inflammation. Mesalazine can inhibit the synthesis of prostaglandins that cause inflammation and the formation of inflammatory mediator leukotrienes, thereby significantly inhibiting intestinal mucosal inflammation.
Packing:
In 25kg fibre drum
Specification
EP10